In a time
when we are more concerned than ever with issues of health, NONI, a
tried and true tropical herb needs to be added to our list of the
best natural remedies. Its usage over hundreds of years supports its
description as possessing a veritable panacea of therapeutic actions.
Noni’s emergence as an effective natural healing agent is a
timely one; herbs like noni are in high demand for their natural
pharmaceutical properties in a time when cancer rates are soaring,
degenerative diseases are widespread, and bacteria and viral strains
are increasingly resistant to contemporary treatments.
All
of us want to know how to:
Protect
ourselves from toxins and pollutants
Prevent
the premature onset of age-related diseases such as arthritis,
heart disease, diabetes and stroke.
Boost
our immune defenses to protect from new viral and bacterial
strains that have become antibiotic-resistant
Reduce
our risk of developing cancer
Better
digest our food for proper assimilation
Noni
has the potential to boost the immune system, inhibit tumor growth,
normalize physiological functions on a cellular level, and stimulate
cell regeneration. Noni appears to have the ability to augment immune
defenses, fight pain, reduce inflammation, and purge the intestinal
system without the dangerous side effects of harsh drugs. Its
impressive and widespread use among various native cultures of
tropical island regions supports the theory that
it possesses valuable, therapeutic compounds.
Noni can be
considered an antibacterial, analgesic, anticongestive, antioxidant,
anticatarrhal, anti-inflammatory, astringent, emollient, emmenagogue,
laxative, sedative, hypotensive (lowers blood pressure), blood
purifier, and tonic.
Noni has various
chemical constituents. First, it has an impressive array of terpene
compounds, three of which---L. Asperuloside, acubin, and
glucose---have been identified by their acetyl derivatives. Both
caprioc and
caprylic acids
have been isolated. Second,bushfruits,
a category of which noni fruit is a member, are also considered a
good source of vitamin C. Third, Hawaiian noni has been linked to the
synthesis of xeronine in the body which has significant and
widespread health implications. Last, the alkaloid content of the
noni fruit is thought to be responsible for its therapeutic actions.
Alkaloids exhibit a wide range of pharmacological and biological
activities in the human body. They are nitrogen-containing organic
compounds that react with acids to form salts, which are the basis of
many medicines. Finally, the ezymatic actions of noni make it
valuable as a health promoter in cells. The following is an in-depth
chemical analysis of the Noni fruit:
antioxidant
alizarin
anthraquinones
caproic
and caprylic acids
essential
oil
B-D
glucopyranose pentaacetate
asperuloside
tetra acetate
glucose
ascorbic
acid (The high ascorbic acid [vitamin C] content of this bushfruit
makes it avaluable
food source.)
Dr.
Ralph Heinicke of the University of Hawaii discovered an alkaloid in
the Hawaiian
noni fruit which he calls proxeronine. Heinicke believes proxeronine
has appreciable physiological benefits by acting as a precursor to
xeronine, a very crucial compound. In addition, a compound found in
the fruit called damnacanthol is believed to help inhibit certain
viruses and cellular mutations involved in cancer.
PHARMACOLOGY:
Recent
surveys have suggested that noni fruit exerts antibiotic action. In
fact, a variety of compounds which have antibacterial properties
(such as aucubin) have been identified in the fruit. The 6-D
glucopyranose pentaacetate of the fruit extract is not considered
bacteriostatic. Constituents found in the fruit portion have
exhibited antimicrobial action against Escherichia coli, Salmonella
typhi (and other types), Shigella paradysenteriae, and Staphylococcus
auraus. Compounds found in the root have the ability to reduce
swollen mucous membrane and lower blood pressure in animal studies.
Proxeronine
is an alkoloid constituent found in Hawaiian noni fruit that prompts
the production of xeronine in the body. Dr. Heinicke, who discovered
proxeronine, theorized that this proenzyme can be effective in
initiating a series of beneficial cellular reactions through
its involvement with the integrity of specific proteins. He points
out that tissues contain cells which possess certain receptor sites
for xeronine. Because the reactions that can occur are so varied,
different therapeutic actions can result when xeronine production
escalates, explaining why Hawaiian noni is good for many seemingly
unrelated disorders.
Damnacanthol
is another compound contained in the fruit of the Hawaiian noni
plant which has shown the ability to block or inhibit the cellular
function of RAS cells, widely considered to be pre-cancerous cells.
BODY
SYSTEMS TARGETED:
Circulatory,
digestive The following body systems have all been effectively
influenced by Noni, respiratory, integumentary (skin) endocrine,
immune, nervous, and skeletal.
SUGGESTED
USES:
Ideally,
noni extracts should be taken on an empty stomach prior to meals.
The process of digesting food can interfere with the medicinal value
of the alkaloid compounds found in Hawaiian noni, especially in its
fruit. Apparently, stomach acids and enzymes destroy the specific
enzyme that frees up the xeronine compound. Using supplements that
have been made from the semi-ripe or light-green fruit is also
considered preferable to the ripe, whitish fruit.
A
TIMELY RE-EMERGENCE:
Today,
the natural pharmaceutical actions of the chemical constituents
contained in noni are scientifically emerging as valuable botanical
medicines. Tahitian "noni" intrigued medical practitioners
decades ago. However, due to the eventual emergence of synthetic
drugs, interest in this island botanical diminished until recent
years. Ethnobotanists are once again rediscovering why Hawaiian
people have treasured and cultivated Morinda citrifolia for
generations. Noni is now finding its way into Western therapeutics
and is referred to as "the queen" of the genus Rubiaceae.
Its ability to reduce joint inflammation and target the immune system
have made it the focus of the modern scientific inquiry.
Studies
investigating noni as an anticancer agent have been encouraging. Its
conspicuous attributes and varied uses have elevated its status to
one of the best of the healing herbs. Today Morinda citrifolia is
available in liquid juice, or freeze-dried capsules, and is
considered one of nature’s most precious botanicals.
XERONINE:
"I
have devoted my life to the study of "Xeronine." I am
convince of Xeronine’s tremendous benefits to the body, Dr.
Ralph Heinicke, Ph.D.
Dr.
Ralph Heinicke, a biochemist, discovered an alkaloid he named
Xeronine while studying pineapple enzymes. He discovered that
Xeronine is produced in the large intestine from key building blocks
called Proxeronine – the precursor to Xeronine – and
Proxeronase, the enzyme catalyst required for the chemical reaction
that makes Xeronine. Dr. Heinicke searched for a reliable, abundant
source of Proxeronin and Proxeronase. He found that the Noni fruit is
the most abundant and reliable source of Proxeronine and
Proxeronase. Dr. Heinicke, a biochemist, has researched the
active compounds of noni fruit for a number of years. He discovered
that the Hawaiian noni fruit contains an alkaloid precursor to a very
vital compound called xeronine. Without xeronine, life would cease.
In
Dr. Heinicke’s view, noni fruit provides a safe and effective
way to increase xeronine levels in the body, profoundly affecting
cell health and protection. His research shows that the juice from
the Morinda citrifolia fruit contains proxeronine, a precursor of the
crucial compound xeronine. Proxeronine initiates the release of
xeronine in the intestinal tract after it comes in contact with a
specific enzyme which is also contained in the fruit. This particular
chemical combination is believed to significantly affect cellular
function for the positive.
PROTEIN
REGULATOR:
Dr.
Heinicke’s research is based on the premise that one of the
primary functions of xeronine is to regulate the shape and integrity
of specific proteins. Because proteins and enzymes have so many
varied roles within cell processes, the normalization of these
proteins with noni supplementation could initiate a very wide variety
of body responses and treat many disease conditions. Proteins are the
most important catalysts found in the body. The beauty of obtaining a
precursor to xeronine from the noni fruit is that the body naturally
decides how much of this precursor to convert to xeronine. Disease,
stress, anger, trauma and injury can lower xeronine levels in the
body, thus creating a xeronine deficit. Supplementing the body with
noni fruit is considered an excellent way to safely and naturally
raise xeronine levels. It is the research and theories of Dr.
Heinicke which have made the juice of the Hawaiian noni fruit a
viable medicinal substance. He writes: Xeronine is an alkaloid,
a substance the body produces in order to activate enzymes so they
can function properly. It also energizes and regulates the body. This
particular alkaloid has never been found because the body makes it,
immediately uses it, and then breaks it down. At no time is there an
appreciable, isolated amount in the blood. But xeronine is so basic
to the functioning of proteins, we would die without it. Its absence
can cause many kinds of illness.
Because
so many diseases result from an enzyme malfunction, Dr. Heinicke
believes that using the noni fruit can result in an impressive array
of curative applications. Interestingly, he believes that we
manufacture proxeronine while we are sleeping. He proposes that if we
could constantly supply our bodies with proxeronine from other
sources, our need to sleep would diminish.
NONI
PROCESSING:
How
an herb is processed is crucial to how beneficial it is. This is
especially true of Noni, with its unique enzymes and alkaloids.
Morinda citrifolia should be picked when the fruit is turning from
its dark green immature color to its lighter green color, and
certainly before it ripens to its white, almost translucent color.
Once picked, noni, like aloe, will denature extremely quickly due to
its very active enzymes. After harvesting, it should swiftly be flash
frozen. This is similar to what is done to fish caught at sea to keep
them fresh. This stops
it from losing its potency while not damaging any of its constituents.
Some
other methods of processing include thermal processing, dehydration
and air drying. Thermal processing is generally found in liquids,
while the dehydrated noni is then milled and encapsulated.
Unfortunately both methods utilize high heat (110o F+), which can
deactivate many of the vital compounds that make noni so important.
Air drying is effective without using damaging heat but has quality
control problems for commercial production.
Our
process is completed without damaging any of this plant’s vital
enzymes and other phytonutrients like xeronine and proxeronine. This
pure high-quality noni fruit juice is a ten to one extract or
concentrate using 10 pounds of noni fruit to get 1 gallon of noni
juice. This is importantbecause
typical noni fruit juices are 88 percent or more water; therefore
you must literally drink gallons of juice to get the same benefits as
the 100% pure form. Most noni juices available on the market are
commercially processed and have water, fruit juices and preservatives
added to them. Traditionally noni juice has a very harsh taste and an
astringent smell, similar to the fruit itself, so water and fruit
juice is usually added to improve the taste. Our noni juice is
100% pure, so you are not paying for water or fruit juice. You are
buying simply 100% pure noni juice.
MODERN
APPLICATIONS OF NONI:
Noni possesses a
wide variety of medicinal properties which originate from its
differing plant components. The fruit and leaves of the shrub exert
antibacterial activities. Its roots promote the expulsion of mucus
and the shrinkage of swollen membranes making it an ideal therapeutic
for nasal congestion, lung infections, and hemmoroids. Noni root
compounds have also shown natural sedative properties as well as the
ability to lower blood pressure. Leaf extracts are able to inhibit
the formation of blood clots. Noni is particularly useful for its
ability to treat painful joint conditions and to resolve skin
inflammations. Many people take noni fruit extracts for hypertension,
painful menstruation, arthritis, gastric ulcers, diabetes, and
depression. Recent studies suggest that its anticancer activity
should also be considered. Concerning the therapeutic potential of
the Hawaiian noni fruit, Dr. Heinicke writes: I have seen the
compound found in noni work wonders. When I was still investigating
its possibilities, I had a friend who was a medical research
scientist administer the proxeronine to a woman who had been comatose
for three months. Two hours after receiving the compound, she sat up
in bed and asked where she was. Noni is probably the best
source of proxeronine that we have today.
Studies and
surveys combine to support the ability of noni to act as an
immuno-stimulant, inhibit the growth of certain tumors, enhance and
normalize cellular function and boost tissue regeneration. It is
considered a powerful blood purifier and contributor to overall homeostasis.
NONI JUICE:
MOLECULAR MIRACLE?
Dr. Heinicke also
believes that the compounds specific to noni fruit juice work to
actually repair damaged cells on a molecular level. The proxeronine
content of noni boosts the body’s production of xeronine, which
appears to be able to regulate the shape and integrity of certain
proteins that individually contribute to specific cellular activities.
Some practitioners
believe that xeronine is best obtained from a noni fruit juice
precursor compound.. The enzymatic reactions that occur with taking
the juice on an empty stomach are what Dr. Heinicke believes set
cellular repair into motion.
IMMUNE SYSTEM:
The alkaloid and
other chemical compounds found in noni have proven themselves to
effectively control or kill over six types of infectious bacterial
strains, including Escherichia coli, salmonella typhi, (and other
types) shigella paradysenteriae, and staphylococcus aureaus. In
addition damnacanthol was able to inhibit the early antigen stage of
the Epstein-Barr virus.
The bioactive
components of the whole plant, combined or in separate portions, have
demonstrated the ability to inhibit several different strains of
bacteria. Anecdotal reports support this action in that noni seems
particularly effective in shortening the duration of certain types of
infection. This may explain why noni is commonly used to treat colds
and flu.
The chemical
constituents found in noni and the possibility that they stimulate
xeronine production—as well as initiate alkaloid therapy –
may explain noni’s reputation for having immuno-stimulatory
properties. Alkaloids have been able to boost phagocytosis which is
the process in which certain white blood cells called macrophages
attack and literally digest infectious organisms. Interestingly, the
anti tumor action of noni has been ascribed to an immune system
response which involves stimulating T-cells.
NUTRITIVE BOOSTER:
More and more
research suggests that because Morinda citrifolia compounds enable
the immune system to function more effectively, taking the herb in
concentrated forms may significantly boost health and performance.
These compounds appear to have the ability to increase the
absorption, assimilation and utilization of vitamins and minerals.
The presence of proxeronine in noni initiates a rise of xeronine in
the intestinal tract which enables the walls of the intestines to
more efficiently absorb various nutrients, especially amino acids.
Vitamins act synergistically with xeronine to nourish all body systems.
In addition, leaf
extracts of the plant have a significant amount of protein and the
fruit contains a substantial ascorbic acid content. Morinda
citrifolia has been considered a food staple in Polynesia for
centuries. Apparently, even soldiers stationed in tropical regions
during World War II learned of the fruit’s ability to boost
endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga,
and Australia used the fruit in cooked and raw forms. Morinda
citrifolia is considered a tonic and is especially recommended for
debilitated conditions.
ANTIOXIDANT:
The process of
aging bombards the body with free radicals which can cause all kinds
of degenerative diseases. The xeronine theory promoted by Dr.
Heinicke submits that as our bodies age, we lose our ability to
synthesize xeronine. To make matters worse, the presence of many
environmental toxins actually blocks the production of xeronine.
Heinicke believes that the proxeronine content of Hawaiian noni fruit
juice can help to block these actions, working as an anti-aging compound.
The phytonutrients
found in noni assist in promoting cell nourishment and protection
from free radicals created by exposure to pollution and other
potentially damaging agents. In addition, Morinda citrifolia contains
selenium, one of the best antioxidant compounds available.
DIABETES:
While scientific
studies are lacking in this particular application of noni, Hawaiians
used various parts of the plant and its fruit to treat blood sugar
disorders. Anecdotal surveys have found that noni is currently
recommended for anyone with diabetes.
PAIN KILLER:
A 1990 study found
that extracts derived from the Morinda citrifolia root have the
ability to kill pain in animal experiments. Interestingly, it was
during this study that the natural sedative action of the root was
also noted. This study involved a French team of scientists who noted
a significant central analgesic activity in laboratory mice. Dr.
Heinicke has stated, "Xeronine also acts as a pain reliever. A
man with very advanced intestinal cancer was given three months to
live. He began taking the proxeronine and lived for a whole year, pain-free."
SKIN HEALING AGENT:
One of the most
prevalent historical uses of noni was in poultice form for cuts,
wounds, abrasions, burns and bruises. Using its fruit extract for
very serious burns has resulted in some extraordinary healing.
Because skin is comprised of protein, it immediately responds to the
presence of xeronine. When the skin is broken of traumatized,
proxeronine enters the affected region from surrounding areas, and
xeronine synthesis subsequently rises, enhancing healing and tissue
regeneration. Burns are especially vulnerable to this biochemical
process. Consequently, boosting xeronine production within a burn
site through the direct application of a noni poultice is considered
quite effective by Dr. Heinicke and his colleagues, who have studied
enzymatic therapy. Concerning burns, he has written: I believe
that each tissue has cells which contain proteins which have receptor
sites for the absorption of xeronine. Certain of these proteins are
the inert forms of enzymes which require absorbed xeronine to become
active, This xeronine, by converting the body’s procollangenase
system into a specific protease, quickly and safely removes the dead
tissue from burns.
CONCLUSION:
There is no
question that the very extensive geographical dispersal and
widespread use of Morinda citrifolia in tropical regions attests to
its credibility as a valuable herbal medicine. While more scientific
study on its biochemical attributes is warranted, what has already
emerged provides substantial validation of its medicinal worth. The
enzymatic theories of Dr. Heinicke do warrant further study, but his
research and experience have already elevated the status of the
Hawaiian noni plant to that of a remarkable healing resource. What
the peoples of the South Pacific have known and practiced for
generations should be incorporated into our modern day search for
disease eradication, and health promotion.
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